Dissecting the influence of HIV infection and treatment with antiretroviral therapy on HPV infection, disease and immunity

Basic data
Continent: 
Africa
Country: 
Tanzania
Partner institution: 
National Medical Research Institute - Mbeya Medical Research Center
City: 
Mbeya
Address: 
P.O Box 2410, Hospital Hill Road, Mbeya Tanzania
Local contact: 
Dr. Leonard Maboko
Implementing organisation
Name of institution: 
Medical Centre of the University of Munich (LMU)
Department: 
Division of Infectious Diseases & Tropical Medicine
Address: 
Leopoldstrasse 5
City: 
80802 Munich
Country: 
Germany
Local contact: 
Sabine Kastner| Dr. Christof Geldmacher | Prof. Dr. Michael Hölscher
Type of project
conducted since: 
Q2 2013 (Beginning of recruitment)
planned period: 
open end follow-up (depends on funding, at least until Q4 2015
Type: 
Medicine (clinical)
Medicine (scientific)
Community
HIV testing
Politics
Keywords: 
HIV, HPV
Supporting organisations
International organisations: 
Mbeya Referral Hospital (MRH), Mbeya, Tansania
Matema Hospital, Matema, Tansania
University of Magdeburg, Germany
University of Münster, Germany
German Cancer Research Center (DKFZ), Germany
Forschungsförderung durch Deutsche Forschungsgesellschaft (DFG) und Deutsches Zentrum für Infektionsforschung (DZIF), Deutschland
Staff
Number total staff: 
18
Number medical staff (Doctors only): 
8
Number non-medical staff: 
10
Research projects
Title project: 
2H Study - Dissecting the influence of HIV infection and treatment with antiretroviral therapy on HPV infection, disease and immunity
Timeframe: 
ongoing
Additional information
Additional information: 
The increase in Papilloma-Virus (HPV) associated uterine cancer in HIV-positive women suggests, that defects in HPV-specific CD4 T-cell response play an important role in the pathogenesis of HPV. The hypothesis is, that depletion and malfunction of HPV-specific t-cell and antibodies response after HIV-infection and after initiation of an antiretroviral therapy (HAART) lead to increased diversity and persistence, and possibly increased rates of reinfection with High Risk HPVs, which promotes the malign cell-transformation. The 2H- Study will analyse the complex interactions between HIV, the immune system and HPV-caused carciogenesis in the era of HAART. Immunodominant antigen regions of the clinical relevant HR HPVs (in HIV-positive women) will be identified in immunocompetent women and build the scientific basis for development of a new therapeutical vaccine. Aims of this study are apart from answering medical relevant questions the building and strengthening of local networks. The university hospital munich is conducting advanced trainings on a regular basis. The international network between german and tanzanian scientists and physicians is strengthened by the implementation of an online platform.